protein
| LRWD1-mediated association of ORC1, ORC2 to chromatin is critical to initiate preRC assembly in G1 and chromatin organization in post-G1 cells |
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directly interacts with the N terminus of ORC2, and the stability of LRWD1 is dependent on its association with ORC2 |
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associates with CDT1 and its inhibitor, geminin |
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LRWD1 associates with ORC2 throughout the cell cycle, with Cdt1 during mitosis and G(1), and with geminin in post-G(1) cells |
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WD repeat containing protein ORC-associated |
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ORC2 associates only with the non-ubiquitinated form of LRWD1, and ORC2 depletion results in the proteasome-mediated destabilization of LRWD1 |
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NFKB is an important regulator for the expression of LRWD1 |