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FLASH GENE
Symbol LRWD1 contributors: mct - updated : 30-01-2014
HGNC name leucine-rich repeats and WD repeat domain containing 1p
HGNC id 21769
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2220 - 647 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific SELECTED Mus musculusAdult
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid Mus musculus
Reproductivespermatocyte Mus musculus
Reproductivespermatozoa Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leucine-rich repeat
  • a WD40 repeat domain, interacting with the origin replication complex (ORC), a protein complex involved in both initiation of DNA replication and heterochromatin silencing
  • HOMOLOGY
    interspecies homolog to murine Lrwd1
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    intracellular,nucleus,chromatin/chromosome,centromere
    text centrosomal localization
    basic FUNCTION
  • may play an important role in spermatogenesis
  • is recruited to pericentric heterochromatin through binding to H3K9me3 and the association of LRWD1 with pericentric heterochromatin is required for heterochromatin silencing and maintenance
  • depletion of LRWD1 and ORC2 leads potentially to increased transcription of major satellite repeats
  • testicular-enriched protein that colocalizes with the centrosome at the base of sperm tail
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRWD1-mediated association of ORC1, ORC2 to chromatin is critical to initiate preRC assembly in G1 and chromatin organization in post-G1 cells
  • directly interacts with the N terminus of ORC2, and the stability of LRWD1 is dependent on its association with ORC2
  • associates with CDT1 and its inhibitor, geminin
  • LRWD1 associates with ORC2 throughout the cell cycle, with Cdt1 during mitosis and G(1), and with geminin in post-G(1) cells
  • WD repeat containing protein ORC-associated
  • ORC2 associates only with the non-ubiquitinated form of LRWD1, and ORC2 depletion results in the proteasome-mediated destabilization of LRWD1
  • NFKB is an important regulator for the expression of LRWD1
  • cell & other
    REGULATION
    Other is ubiquitinated at the WD40 repeat domain, a region that is also recognized by ORC2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS