basic FUNCTION
| playing a role in cytokinesis, cell shape, and specialized functions such as secretion and capping |
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reorganizing the cytoskeleton in megakaryocytes and required for efficient platelet production |
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playing a role in the development and maintenance of auditory function |
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required for a critical step between natural killer immunological synapse formation and granule exocytosis ) |
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negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway |
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with MYH14, modulates neuronal cell adhesion |
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myosins IIA and IIB (MYH9 and MYH10), participate in neuronal adhesion, outgrowth and retraction |
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directly regulates cellular patterning and alignment within the cochlear sensory epithelium |
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MYH9, MYH10, MYH14 are involved in regulating cardiac myocyte karyokinesis by affecting microtubule dynamics |
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MYH9, MYH10, MYH14 are a group of molecular motors involved in a wide variety of cellular processes including cytokinesis, migration, and control of cell morphology |
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although MYH9 and MYH10 form filaments with similar properties, MYH14 forms filaments that are less well suited to roles such as tension maintenance within the cell |
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distribution of organelles within platelets critically depends on a homogeneous organelle distribution within megakaryocyte (MK) and preplatelet fragments, which requires MYH9 |
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is critical for generating force during active protrusion |
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role for MYH9 and MYH10 as negative regulators of proliferation in the mammary epithelium |
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MYH9 plays a role in steering migration by maintaining stable protrusions in the anterior region, whereas MYH10 plays a role in maintenance of front-rear polarity by preventing aberrant protrusion formation in the posterior region |
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MTA1-S100A4-MYH9 axis exists in endothelial cells as a novel pathway in promoting tumor vascular formation |
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in adherens junction biogenesis, provides the mechanical tugging force necessary for cell-cell junction reinforcement and maintenance |
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complementary functions of MYH9, MYH10 in the biogenesis and integrity of Adherens junction (AJ) |