Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CUL9 contributors: mct - updated : 30-11-2011
HGNC name cullin 9
HGNC id 15982
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
41 - 7771 - 2517 - 2011 21487039
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • critical regulator in controlling TP53 subcellular localization and subsequent function
  • CUL9-interacting peptides are promising candidates for the enhancement of TP53-dependent apoptosis in tumors with wild type cytoplasmic TP53
  • E3 ubiquitin ligase that binds to TP53 and localizes in the cytoplasm
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • intricate assembly of CUL9- and CUL7-containing complexes is highly regulated, and multiple subcomplexes may exhibit ubiquitin ligase activity
  • interaction with TP53 (function of CUL9 in tumor suppression is largely mediated by TP53)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS