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FLASH GENE
Symbol RFTN1 contributors: mct - updated : 21-09-2011
HGNC name raftlin, lipid raft linker 1
HGNC id 30278
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3033 - 578 - 2011 21266579
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell Homo sapiens
Lymphoid/ImmuneT cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
text translocation of Raftlin from the cytoplasm to the plasma membrane
basic FUNCTION
  • may play a pivotal role in the formation and/or maintenance of lipid rafts, therefore regulating BCR-mediated signaling
  • modulates TCR signals and is necessary for the fine-tuning of T cell-mediated immune responses (
  • cooperates with the uptake receptor to mediate cell entry of the double-stranded RNA analog, poly(I:C), which is critical for activation of TLR3
  • major lipid raft protein expressed by B cells, playing a critical role in poly(I:C) cellular uptake in human myeloid dendritic cells and epithelial cells
  • involved in the nucleocapture complex triggering poly(I:C)-mediated TLR3 activation, and appears to act downstream of immune receptors in a cell type-specific manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS