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FLASH GENE
Symbol MIR96 contributors: mct - updated : 21-09-2011
HGNC name microRNA 96
HGNC id 31648
RNA
TRANSCRIPTS type untranslated small cytoplasmic
EXPRESSION
Rna function
  • may play an important role in promoting proliferation of human breast cancer cells
  • regulates the progression of the physiological and morphological differentiation of cochlear hair cells and, as such, coordinates one of the most distinctive functional refinements of the mammalian auditory system
  • involved in the maturation of the hair cell stereocilia bundle and the remodelling of auditory nerve connections within the cochlea
    • Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea highly Homo sapiens
    Respiratorynose   highly Homo sapiens
    Visualeye   highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumhair cell receptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text
  • highly dynamic during the development of the cochlea, from the patterning to the differentiation of the main cochlear structures
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targeting of FOXO1 by MIR96 may contribute to transformation or maintenance of an oncogenic state in breast cancer cells
  • directly targets the KRAS oncogene and functions as a tumor-suppressing miRNA in pancreatic cancer cells
  • potent regulator of KRAS
  • MIR96 downregulated FOXO3 expression by directly targeting the FOXO3a 3prime-untranslated region
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNA50
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    markedly upregulated in breast cancer cells and breast cancer tissues compared with normal breast epithelial cells (NBEC) and normal breast tissues (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS