basic FUNCTION
| is not an inert scaffold protein, but may play tumor-associated roles during cancer biogenesis |
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may be playing important regulating roles in bone metabolism |
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ubiquitin-binding and ubiquitin-like-domain-containing protein |
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functions as a novel component of the linear ubiquitin chain assembly complex (LUBAC) |
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activates NF-KB and inhibits apoptosis via distinct pathways |
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potentially regulates mitochondria-dependent apoptosis in keratinocytes |
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might play a role in the TLR pathway |
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essential adaptor downstream of the branch point defined by the panr2 mutation in IKBKG |
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controls expression of a subset of TLR2-induced and NFKB– and AP1–dependent genes that overlaps with those affected by the hypomorphic panr2 mutation in IKBKG |
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an important inactivator of beta1-integrins in an RNAi screen |
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inhibits the critical switching of beta1-integrins from inactive to active conformations ( |
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has the ability to self-associate into dimers but rather unexpectedly shows that dimerization is not mediated by a coiled coil but that SHARPIN utilizes the pleckstrin homology (PH) superfold as a dimerization module instead |