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FLASH GENE
Symbol CHP2 contributors: mct - updated : 11-05-2011
HGNC name calcineurin B homologous protein 2
HGNC id
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2391 - 196 - 2003 12576672
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestine  predominantly Homo sapiens
 intestinesmall intestine  predominantly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal region of CHP2 contains a nuclear export sequence (NES), that, with calcium, control the subcellular distribution of CHP2 (
  • N-myristolated and include EF-hand motifs that bind Ca2+ (
  • HOMOLOGY
    Homologene
    FAMILY calcineurin B homologous protein family
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • serves as an obligatory subunit that is required both for supporting the basic activity and regulating the pH-sensing of SLC9A1 via interactions between distinct parts of these proteins )
  • required for histone H3 lysine 14 (H3K14) deacetylation, and mediates transcriptional repression by limiting RNA polymerase II access to heterochromatin
  • involved in transcriptional silencing at heterochromatic regions (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with the histone histone deacetylase complex, is required for histone H3 lysine 14 (H3K14) deacetylation, and mediates transcriptional repression by limiting RNA polymerase II access to heterochromatin
  • interaction between CHP2 and SLC9A 1 (NHE1), two membrane proteins, is essential for protecting cells from serum deprivation-induced death
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    affects the biological behavior of ovarian cancer cell line OVCAR3 and is one of key mechanisms for ovarian carcinoma progression (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may be an attractive target for biological anticancer therapy
    ANIMAL & CELL MODELS