SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleoplasm
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text
| not apparently associate with centrosomes and is predominantly nuclear in localization |
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in interphase cells, WDR62 had weak, diffuse cytoplasmic expression and was not nuclear |
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MAPKBP1 is recruited to mitotic spindle poles (MSPs) during the early phases of mitosis where it colocalizes with its paralog WDR62, which plays a key role at MSP |
basic FUNCTION
| scaffold JNK-binding protein, potentiating JNK kinase activity |
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recruited to stress granules and mediates a nonclassical JNK activation |
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WD40 repeat-containing protein which localizes to the spindle poles of dividing cells |
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spindle pole protein that is expressed in neuronal precursor cells undergoing mitosis in the mammalian embryonic neuroepithelium |
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acts at a critical hub of human cerebral development |
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requirement for MAPK/WDR62 signaling in mitotic spindle regulation that may be involved in coordinating neurogenesis |
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has a role in early cortical development |
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is a novel scaffold protein of the c-Jun N-terminal kinase (JNK) pathway |
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acts upstream of JNK signaling in the control of neurogenesis |
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is required for proper neurogenesis via MAPK8, providing an insight into the molecular mechanisms underlying MCPH pathogenesis |
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spindle pole protein required for normal cell division and neuroprogenitor differentiation during brain development |