basic FUNCTION
| death effector domains protein that negatively regulates both T cell receptor and Toll-like receptor signaling |
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has an essential role in immune homeostasis |
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having tissue-specific functions in both lymphoid and non-lymphoid compartments and its deficiency enhanced cellular but not humoral immunity |
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TNFAIP8L1, TNFAIP8L2, TNFAIP8L3, share high degrees of sequence homology and involve in proliferation, inflammation, and cell death |
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essential negative regulator of both innate and adaptive immunity and its depletion would cause serve inflammatory disease |
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is an inhibitor of both inflammation and cancer |
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is involved in the pathogenesis of stroke, suggesting that it plays an essential role in a signal transduction pathway that links the inflammatory immune response to specific conditions after cerebral ischemia |
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serves as a negative regulator of innate immunity by linking TLRs to RAC1 |
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controls innate immunity by targeting the Rac GTPases |
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inhibits immunity to bacteria |
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is a potential inhibitor of atherosclerosis |
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can negatively regulate inflammation through inhibiting immune receptor signaling, and plays a crucial atheroprotective role likely by regulating macrophage responses to oxidized low-density lipoprotein (ox-LDL) |
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plays an important role in shifting L-arginase metabolism from production of nitric oxide (NO) to urea, during host inflammatory response |
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is an inhibitor of gastric cancer cell growth, and likely might promote a CDKN1B-associated signaling cascade that leads to restored control of the cell cycle and cell division |
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might serve as a tumor suppressor in NSCLC progression |
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inhibited the phosphorylation of AKT1, while promoting the phosphorylation of MAPK14, but had no effect on NFKBIA and ERK pathway |
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negative regulator of innate and adaptive immunity which participates in inflammatory homeostasis |
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anti-inflammatory TNFAIP8L2 inhibits angiogenic VEGFA in retinal pigment epithelium |
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plays a key role in non-small cell lung cancer (NSCLC) metastasis |
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death effector domain protein that is a negative regulator of the innate and adaptive immune response |
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acts as a novel negative regulator of inflammatory and immune responses through MAP3K7 signaling |
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involved in the invasion and metastasis of human tumors |
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its overexpression may suppress proliferation, migration, and invasion in prostate cancer cells by inhibiting the PI3K/AKT1 signaling pathway |
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suppressed breast cancer tumorigenesis, growth and metastasis possibly via regulation of the AKT1 and MAPK14 signaling pathways |