Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ZNF580

contributors: mct - updated : 31-08-2010

HGNC name	zinc finger protein 580
HGNC id	29473

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001163423 2 - 1046 NP_001156895 18.8 172 - Sun (2010) NM_016202 1 - 1433 NP_057286 18.8 172 - Sun (2010) NM_207115 2 - 1152 NP_996998 18.8 172 - Sun (2010)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

three repeated tandem C2H2-type zinc finger motifs at its C-terminus

HOMOLOGY

Homologene

FAMILY

CATEGORY

motor/contractile , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	could localize into the nuclei (Sun 2010)

basic FUNCTION	important role in the process of migration and proliferation of endothelial cells, which provides a foundation for a novel approach to regulate angiogenesis (Sun 2010)
	may be involved in transcriptional regulation of angiogenesis (Sun 2010)
	mediates S1P/MAPK14 signaling to promote endothelial cell migration and proliferation (Sun 2010)

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	ZN2+

protein	associated with LDL stimulation in vascular endothelial cells (Sun 2010)
	regulates MMP2 expression in endothelial cells (MMP2 mRNA expression and its enzymatic activity was correlated with the expression of ZNF580)(Sun 2010)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS