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FLASH GENE
Symbol GYPC contributors: mct - updated : 28-11-2018
HGNC name glycophorin C (Gerbich blood group)
HGNC id 4704
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1249 13.7 128 - 2003 12469115
3 - 1192 11.8 109 - 2003 12469115
5 - 2067 - 107 - 2003 12469115
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeanterior segment   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerthrocyte
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
CATEGORY antigen
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytoskeleton
text type3 membrane protein
basic FUNCTION
  • plasmodium falciparum receptor, playing an important role in regulating the stability of red cells
  • encodes two erythrocyte surface sialoglycoproteins in humans, glycophorin C and glycophorin D (GYPC and GYPD), via initiation of translation at two start codons on a single transcript
  • crucial role of GYPC for P. berghei infection
  • GYPA, GYPB receptor are of greater importance than the GYPC receptor, supporting a hierarchy of erythrocyte receptor usage in P. falciparum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GRBG
    related resource Blood Group Antigen Mutation Database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS