protein
| binds the GLI-binding consensus sequence in the GLI1 promoter (GLI2 directly activates GLI1) |
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interacting with SUFU and SPOP (SUFU regulates GLI protein levels by antagonizing the activity of SPOP, a conserved GLI-degrading factor) |
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PIAS1-dependent SUMOylation influences GLI1, GLI2, GLI3 protein activity and thereby identifies SUMOylation as a post-translational mechanism that regulates the hedgehog signaling pathway |
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IFT122 leads to accumulation of GLI2 and GLI3 at cilia tips while blocking the ciliary localization of the antagonist TULP3 |
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CCL5-GLI2-IL6 interaction in B cell malignancies regulates immunoglobulin secretion |
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potentially, upon Hedgehog input, GLI1 functions collectively with GLI2 and GLI3 in osteogenesis |
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GLI2, is a direct transcriptional target of the TGFB1/SMAD pathway and contributes to melanoma progression, exerting antagonistic activities against M-MITF to control melanoma cell invasiveness |
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SUMO modification inhibits GLI2 transcriptional activity by recruiting HDAC5 |
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TMEM107 acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types |
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KIF7 is required to establish high intracellular GLI activity by antagonizing the SUFU-inhibition of GLI2 |
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GLI1 and GLI2 activated the expression of a basic helix-loop-helix type suppressor BHLHE41 through a GLI-binding site in the promoter |
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PKD1L1-PKD2L1 acts as a ciliary calcium channel controlling ciliary calcium concentration and thereby modifying SMO-activated GLI2 translocation and GLI1 expression |
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GLI1, GLI2, GLI3 interacts synergistically with KIFAP3 and KIF3A |
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TAF9 interacts with the oncogenic GLI family members GLI1 and GLI2 but not GLI3 |
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SPOP targets GLI2 and GLI3 for degradation and negatively regulates Hedgehog (Hh) signaling |
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GLI1 and GLI2 directly bind to the promoter regions of NEK2 gene and induced its transcription |
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OTUB2 is a regulator of GLI2 protein degradation |