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FLASH GENE
Symbol HEATR3 contributors: mct - updated : 06-02-2023
HGNC name HEAT repeat containing 3
HGNC id 26087
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 4416 74.45 680 - 2015 25849277
16 - 4757 - 563 - 2015 25849277
16 - 4731 - 563 - 2015 25849277
14 - 4306 - 449 - 2015 25849277
EXPRESSION
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four N-terminal Armadillo (ARM) repeats
  • six C-terminal HEAT repeats
  • HOMOLOGY
    interspecies ortholog to yeast Syo1 protein
    Homologene
    FAMILY
  • HEAT repeat family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • dual role of HEATR3 in ribosomal protein transport and as an assembly platform for 5S RNP
  • HEATR3, like RPL5 and RPL11, may function as a tumor suppressor and a likely causative gene in the congenital disorder DBA through its role in modulating TP53
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a ribosome assembly factor required for mammalian 60S ribosomal subunit assembly through binding of RPL5 and RPL11
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA21
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS