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FLASH GENE
Symbol DSTYK contributors: mct - updated : 15-03-2017
HGNC name dual serine/threonine and tyrosine protein kinase
HGNC id 29043
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 7791 99.8 884 - 2006 17123648
13 - 7926 105 929 - 2006 17123648
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumear   highly
Nervousbraindiencephalonhypothalamus highly Homo sapiens
 spinal cord     Homo sapiens
Skin/Tegumentskin   highly Homo sapiens
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • non-catalytic region has eight conserved cysteine residues
  • a large unconserved N-terminal domain
  • multiple potential kinase-docking motifs
  • phosphorylation sites
  • catalytic domain is divergent and about equally distant of Ser/Thr and Tyr protein kinases
  • C-terminus containing a kinase domain, which is mostly homologous with the kinase domain of RIP
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • CATEGORY receptor serine/threonine tyrosine kinase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • putative dual Ser/Thr and Tyr protein kinase, displaying an increasing degree of sequence conservation from the N-terminal non-catalytic domain to C-terminal catalytic domain
  • is a unique evolutionarily selected group of divergent protein kinases that may play important functional roles in the brain and other tissues of vertebrates
  • may play important functional roles in the brain and other tissues of vertebrates
  • may induce both caspase-dependent apoptosis and caspase-independent cell death
  • is a major determinant of human urinary tract development
  • may play important roles in brain because of its high expression in most brain areas
  • acts to suppress apoptosis in response to UV-induced stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG23 , CAKUT1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Dstyk homozygous KO mice show impaired capabilities of learning and memory compared with the Dstyk heterozygous KO mice