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FLASH GENE
Symbol CT55 contributors: mct - updated : 05-06-2020
HGNC name cancer/testis antigen 55
HGNC id 26047
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1441 29 264 - 2017 28862699
5 - 2188 26.5 242 - 2017 28862699
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland    
Endocrineadrenal gland    
Reproductivemale systemtestis    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • CT55 functions in Colitis-associated cancer (CAC) are dependent on TNF-induced NFKB1 signaling
  • may be involved in colitis-associated colon tumorigenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mechanistically, CT55 acts as an accelerator of tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NFKB1) signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    suppresses the development of Colitis-associated cancer (CAC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • mRNA positivity of CXORF48, MAGEB6, and CRISP2 presented significant associations with recognized clinical features for poor outcome in head and neck squamous cell carcinoma (HNSCC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    could be a promising therapeutic target of leukemic stem cells (LSCs) for immunotherapy to obtain durable treatment-free remission in CML patients
    cancerdigestivecolon
    could be a novel target for CAC treatment
    ANIMAL & CELL MODELS
  • Ct55-deficient mice were resistant to CAC in a colitis-associated colon cancer model