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FLASH GENE

Symbol

SDE2

contributors: npt - updated : 02-12-2020

HGNC name	SDE2 telomere maintenance homolog
HGNC id	26643

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152608 7 - 3987 NP_689821 49.6 451 - 2019 30698750

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Reproductive female system uterus cervix     Urinary bladder

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal ubiquitin-like (UBL) fold, which is cleaved at a diglycine motif via a PCNA-interacting peptide (PIP) box and deubiquitinating enzyme activity, and UBL domain plays an important role in regulating replication stress response
	a DNA-binding SAP (SAF-A/B, Acinus and PIAS) domain (SAP domains are frequently found in proteins participating in the DNA repair process)
	cleaved C-terminal SDE2 is required for antagonizing PCNA monoubiquitination triggered by ultraviolet (UV) damage

HOMOLOGY

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles

basic FUNCTION	possible function in the DDR or in DNA repair
	may be involved in a confined and specific DNA repair pathway, which is often the case with distinct DNA repair factors
	is a new factor required for counteracting replication stress
	PCNA-associated protein, playing a key role in maintaining active replication and counteracting replication stress by regulating the replication fork protection complex (FPC)
	essential role for SDE2 in maintaining genomic integrity by stabilizing the FPC

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	SDE2 is a new genome surveillance factor regulated by PCNA interaction
	SDE2 facilitates spliceosomal association of CACTIN/Cay1, with a functional link between SDE2 and CACTIN further supported by genetic interactions and pre-mRNA splicing assays
	conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks
	SDE2 directly interacts with the FPC component TIMELESS (TIM) and enhances its stability, thereby aiding TIM localization to replication forks and the coordination of replisome progression

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS