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FLASH GENE
Symbol HSPB11 contributors: npt/mct - updated : 29-08-2017
HGNC name heat shock protein family B (small), member 11
HGNC id 25019
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 601 16.2 144 - Bellyei (2007)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 parathyroid   highly
Reproductivemale systemtestis  highly Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY chaperone/stress , unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
  • formed oligomeric complexes in aqueous solution
  • could be modified covalently by poly(ADP ribosylation) and acetylation
  • can prevent the destabilization of mitochondrial membrane systems and could represent a suitable target for modulating cell death pathways
  • may have relevance as becoming a possible tumor marker
  • although not necessary for the formation of cilia in somatic cells, is likely indispensable for sperm flagellum formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the IFT complex not required for the formation of cilia in somatic tissues
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HSPB11 directly interacts with IFT27, and these two proteins likely form a subcomplex (association and disassociation between the subcomplex of HSPB11 and IFT27 and complex B might be involved in the regulation of IFT)
  • IFT52 binds directly to four other IFT-B subunits, IFT81/74/27/HSPB11
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    displayed increased expression in neuroectodermal tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS