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FLASH GENE
Symbol COL6A5 contributors: mct - updated : 15-06-2013
HGNC name collagen, type VI, alpha 5
HGNC id 26674
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
40 - 8878 277.71 2526 - 2008 18400749
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon   Homo sapiensAdultmRNA
Reproductivemale systemtestis    Homo sapiensAdultmRNA
Respiratorylung     Homo sapiensAdultmRNA
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 336-AA triple helix flanked by seven N-terminal von Willebrand factor A-like domains
  • a collagenous domain
  • three C-terminal von Willebrand factor A domains, and a unique domain
  • HOMOLOGY
    Homologene
    FAMILY
  • type VI collagen family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • playing a role in epidermal integrity and function, the breakdown of which is a clinical hallmark of atopic dermatitis
  • may have a specialized function in tissue areas subjected to tensile stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to atopic dermatitis
  • to AD pathogenesis and chronic obstructive pulmonary disease and asthma
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS