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FLASH GENE
Symbol CENPN contributors: SGE - updated : 30/09/2008
HGNC name centromere protein N
HGNC id 30873
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 splicing 4659 39.4 339 - -
  • isoform 2
  • 11 splicing 2265 41 353 - -
  • isoform 1
  • 7 splicing 1465 23.9 204 - -
  • isoform 3
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   predominantly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuteruscervix moderately
     male systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer complex
    HOMOLOGY
    interspecies homolog to rattus Cenpn (71.9 pc)
    homolog to murine Cenpn (73.3 pc)
    homolog to chicken CENPN (61 pc)
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    basic FUNCTION
  • playing a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation
  • recruiting the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres
  • CELLULAR PROCESS cell cycle, division, mitosis
    nucleotide, genomic integrity
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CENPA-NAC (nucleosome-associated) complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU
  • constitutive centromere-associated network (CCAN) component (Hori 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS
  • binding selectively CENPA-nucleosomes but not H3-nucleosomes and recruiting other proteins to centromeric chromatin that are required for centromere function and propagation (Carroll 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS