basic FUNCTION
| SKA complex functionally complements the KMN network (CASC5, MIS12, NDC80) providing an additional layer of stability to kinetochore-microtubule attachment and possibly signalling completion of attachment to the spindle checkpoint |
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SKA1, SKA2 and SKA3 are required for stabilizing kinetochore-microtubule (KT-MT) interactions and silencing spindle checkpoint during mitosis |
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critical role of the Ska complex in maintaining a firm grip on dynamic microtubules |
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microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation |
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is required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint |