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FLASH GENE
Symbol IL34 contributors: mct - updated : 24-03-2012
HGNC name interleukin 34
HGNC id 28529
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1779 27 242 - 2010 20504948
7 - 1796 - 242 - 2010 20504948
7 - 1793 - 241 - 2010 20504948
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • functional overlap but differential expression of CSF1 and IL34 in their CSF1 receptor-mediated regulation of myeloid cells
  • important player in osteoclastogenesis and thus may have a role in bone diseases
  • cytokine implicated in macrophage differentiation and osteoclastogenesis
  • as a downstream effector of TNF and IL1B, may contribute to inflammation and bone erosions in rheumatoid arthritis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a ligand of CSF1R
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS