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FLASH GENE
Symbol XXYLT1 contributors: mct - updated : 18-12-2013
HGNC name xyloside xylosyltransferase 1
HGNC id 26639
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2830 43 393 - 2010 20876614
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel    
Digestivesalivary gland    
Endocrineadrenal gland    
Lymphoid/Immunespleen    
Reproductivefemale systemuteruscervix  
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal cleavable signal sequence rather than an N-terminal signal anchor
  • lacking the predicted membrane-bound domain
  • two conserved DXD motifs
  • HOMOLOGY
    Homologene
    FAMILY
  • glycosyltransferase 8 family (GT8 family)
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • most likely is a typical type II transmembrane protein, but localized in the ER
  • basic FUNCTION
  • typical type II membrane-bound glycosyltransferase localized in the endoplasmic reticulum
  • elongates the Xyl-Glc-O-Ser disaccharide on Notch EGF repeats
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to non-small cell lung cancer (NSCLC)
    Variant & Polymorphism other
  • presence of the variant allele in C3orf21 is a risk factor for NSCLC
  • Candidate gene
    Marker
  • important marker of genetic susceptibility to lung cancer in Koreans
  • Therapy target
    ANIMAL & CELL MODELS