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FLASH GENE
Symbol FNIP2 contributors: mct - updated : 09-09-2014
HGNC name folliculin interacting protein 2
HGNC id 29280
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 5801 122 1114 - 2008 18403135
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to FNIP1
Homologene
FAMILY
  • FNIP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may play a role in renal carcinogenesis
  • activation of AMPK by FNIP2 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA
  • proapoptotic function of FNIP2 may be regulated by AMPK and FLCN through stabilization of FNIP2 itself
  • its level is regulated by proteasome-dependent degradation pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • form homo- and heteromeric multimers with FNIP1
  • part of of FLCN-AMPK-FNIP complex which is regulated by Ser62 phosphorylation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the C-terminal half of the folliculin tumor suppressor protein and with an important nutrient- and energy-sensing molecule, AMPK, a negative regulator of FRAP1
  • FLCN retains an ability to stably bind to FNIP2 during apoptosis , and FNIP2 may interact with folliculin and AMPK in a specific manner during the course of apoptosis
  • proapoptotic function of FNIP2 may be regulated by AMPK and FLCN through stabilization of FNIP2 itself
  • FLCN-GABARAP association is modulated by the presence of either folliculin-interacting protein FNIP1 or FNIP2 and further regulated by ULK1
  • cell & other
    REGULATION
    Other stabilization of FNIP2 is regulated through its specific interaction with folliculin and AMPK
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in sporadic clear cell renal carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS