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FLASH GENE
Symbol ADAT3 contributors: mct/npt - updated : 26-06-2008
HGNC name adenosine deaminase, tRNA-specific 3, TAD3 homolog (S. cerevisiae)
HGNC id 25151
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1597 38 351 - Schaub (2002)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
interspecies homolog to S. Cerevisiae Tad3
Homologene
FAMILY
  • cytidine and deoxycytidylate deaminase family
  • ADAT3 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in inosine formation in tRNAs
  • with ADAT2 function as a heterodimer which catalyses inosine formation at the wobble position (position 34) in eukaryotic tRNAs
  • playing an essential role for cell viability, illustrating the biological importance of A-to-I editing at the wobble position of tRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS