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FLASH GENE
Symbol ALKAL2 contributors: mct - updated : 25-10-2019
HGNC name ALK and LTK ligand 2
HGNC id 27683
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1184 - 152 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel    
Endocrineneuroendocrinepituitary   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
  • FAM150 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • physiological link between augmentor ligands (FAM150A, FAM150B) and LTK and particular augmentors activate LTK in a tissue-specific context to induce iridophore differentiation from neural crest-derived cells and pigment progenitor cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ALKAL1 and ALKAL2 are potent ligands for human ALK that bind to the extracellular domain of ALK and in addition to activation of wild-type ALK are able to drive 'superactivation' of activated ALK mutants from neuroblastoma
  • . ALKAL2 binds ALK with high affinity and activates ALK in cells with subnanomolar potency
  • binds and robustly activates both ALK and LTK
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS