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FLASH GENE
Symbol MAU2 contributors: mct/ - updated : 05-12-2017
HGNC name MAU2 chromatid cohesion factor homolog (C. elegans)
HGNC id 29140
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 4853 69 613 - 2006 16682347
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • mau-2 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression
  • a conserved patch on the surface of MAU2 is required to recruit NIPBL/MAU2 to centromeres and to build pericentromeric cohesion
  • balanced activity of NIPBL/MAU2 and WAPL enables cohesin to correctly structure chromosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • kollerin complex, consisting of NIPBL/MAU2 in vertebrates, is crucial for the chromatin-association of the cohesin complex and therefore for the critical functions of cohesin in cell division, transcriptional regulation and chromatin organisation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NIPBL/Scc2 functionally interacts with the MAU2/Scc4 protein to initiate loading of cohesin onto chromatin
  • MAU2/NIPBL protein interaction is not only required for cohesin loading, but may also be required to restrict the level of NIPBL involved in regulating gene expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS