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FLASH GENE
Symbol CMPK2 contributors: mct - updated : 13-02-2008
HGNC name cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
HGNC id 27015
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3009 - 449 - Xu (2008)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal targeting signal
  • C-terminal domain containing all consensus motifs of a nucleoside monophosphate kinase
  • HOMOLOGY
    intraspecies homolog to high homology with TMPK
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity
  • first pyrimidine nucleoside monophosphate kinase that has been identified in mitochondria
  • may be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein able to phosphorylate dUMP, dCMP, CMP, and UMP with ATP as phosphate donor
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS