protein
| is a catalytically active serine protease that is inhibited by the two Kunitz type serine protease inhibitors, hepatocyte growth factor activator inhibitor SPINT1 and SPINT2, as well as by SERPINA1 |
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TMPRSS11B promotes solubilization of BSG, an obligate chaperone of SLC16A4, which enhances lactate export and glycolytic metabolism, thereby promoting tumorigenesis |
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TMPRSS11B interacts with BSG and SLC16A4 at the plasma membrane, and TMPRSS11B may influence trafficking of BSG to the plasma membrane |