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FLASH GENE
Symbol CASR contributors: mct - updated : 18-12-2015
HGNC name calcium-sensing receptor
HGNC id 1514
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 4924 120.7 1078 - 1995 7673400
6 splicing 5011 - 1088 - 1995 7673400
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   predominantly
Nervousbrainlimbic systemhippocampus   Homo sapiens
 brainforebraincerebral lobefrontal lobe  Homo sapiens
 brainforebraincerebral lobeparietal lobe  Homo sapiens
 brainhindbraincerebellum   Homo sapiens
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a large N terminal extracellular ligand binding domain including clusters of acidic AAs ressembling the site of low affinity Ca++ binding proteins
  • a seven transmembrane-spanning segment
  • a C terminal intracytoplasmic tail, with a cellular sorting signal encoded by 51 AAs in the carboxyl tail containing a PEST-like motif, contributing to receptor entry into late endosomes or lysosomal compartments for possible degradation
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Casr/Gprc2a
    Homologene
    FAMILY
  • G-protein coupled receptor 3 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text at the plasma membrane as a homodimer, and dimerized in the ER
    basic FUNCTION
  • functioning as a sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration
  • activating phospholipase C
  • possibility of involvement of CASR in pathophysiology of epileptic disorders
  • putatively involved in the regulation of insulin release
  • can regulate parathyroid hormone gene expression in heterologous cells
  • regulates extracellular calcium ion homeostasis by controlling the rate of parathyroid hormone secretion from the parathyroid gland and the rate of calcium re-absorption by the kidney
  • plays an integral role in calcium homeostasis and the regulation of other cellular functions including cell proliferation and cytoskeletal organisation
  • key role for CASR-induced phospholipase C activation and the release of intracellular calcium
  • in adipocytes may be involved in the pathogenesis of obesity by promoting adipocyte differentiation and adipogenesis
  • key role in normal epidermal development
  • specifically modulates nuclear Ca(2+) signalling through the IP3 receptors pathway
  • essential role in systemic calcium homeostasis through its ability to sense small changes in circulating calcium concentration and to couple this information to intracellular signaling pathways that influence parathyroid hormone secretion
  • role in other cellular functions including the control of cellular proliferation, differentiation and apoptosis
  • contributes to maintain homeostatic levels of extracellular calcium
  • controls other cellular activities such as proliferation and migration, particularly in cells not related to extracellular calcium homeostasis
  • CASR and GPR68 reciprocally inhibit signaling through each other in central neurons, but strong intracellular acidification impairs CASR function, and potentiates GPR68 function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text Ca2+ homeostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • modified by PTH
  • interacts directly with KCNJ10 and KCNJ15 and can decrease their currents, which in turn could reduce recycling of K(+) for the basolateral Na(+)-K(+)-ATPase and thereby contribute to inhibition of Na(+) reabsorption
  • interacting with TRPV5 (activation of CASR stimulates the activity of the epithelial Ca2+ channel TRPV5)
  • interplay between the CASR and testin in the regulation of CASR-mediated Rho signalling with possible effects on the cytoskeleton
  • recognition of extracellular Ca2+ through CASR activates the NLRP3 inflammasome
  • CASR interacts with GPR39 and thereby regulates its activity
  • CASR interferes with TGFB1-dependent SMAD2 phosphorylation and induces its proteasomal degradation, resulting in a decrease of TGFB1-dependent transcriptional activity
  • might regulate TGFB1-dependent cellular responses mediated by TGFB1 signaling inhibition
  • cell & other
    REGULATION
    inhibited by disruptions of endogenous SAR1A1 function, attenuates cell surface expression of CASR
    Other transactivation of the CASR promoter by GCM2 completely abolished in the presence of the dominant-negative mutant GCM2
    ASSOCIATED DISORDERS
    corresponding disease(s) HHC1 , HPT2 , NSHPT , HYPOCA , HYPOCAB , EIG8
    related resource CASR DB Calcium Sensing Receptor Locus Mutation Database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    by elevated Ca2+(o) concentrations, such as those found near resorbing bone, produces an especially strong chemoattractant effect on bone metastatic breast cancer cells toward the Ca2+-rich environment
    tumoral        
    silenced by genetic and epigenetic mechanisms in unfavorable neuroblastomas
    constitutional     --over  
    in inflammatory states, such as that associated with obesity
    Susceptibility to chronic pancreatitis
    Variant & Polymorphism SNP higher in a healthy group with the S986S genotype
    Candidate gene
  • is one of the candidate genes explaining individual predisposition to calcium nephrolithiasis
  • Marker
    Therapy target
    ANIMAL & CELL MODELS