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FLASH GENE
Symbol SAP30L contributors: mct - updated : 27-08-2012
HGNC name SAP30-like
HGNC id 25663
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 6243 - 183 - 2008 18070604
also called variant 1
3 - 6120 - 142 - 2008 18070604
  • also called variant 2 or delta EX2
  • exons 1-3-4
  • evinced a slightly reduced transcriptional repression activity compared to wt SAP30L
  • 3 - 6105 - 137 - 2008 18070604
  • also called variant 3 or delta EX2 delta5
  • exons 1-3-4
  • lacks a further five amino acids, had almost five times less repression activity compared to wt SAP30L
  • - - - - - - 2008 18070604
  • also called Ldelta EX3,4
  • exons 1-2
  • located partly in the cytoplasm and the nucleus but not in the nucleolus
  • unable to associate with SIN3A
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to SIN3A (70p100)
    Homologene
    FAMILY
  • SAP30 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • might have a role in recruiting the Sin3-histone deacetylase complex to specific corepressor complexes in response to TGF-beta, leading to the silencing of proliferation-driving genes in the differentiating intestinal epithelial cells
  • inducing transcriptional repression, possibly via recruitment of Sin3A and histone deacetylases
  • SAP30L and SAP30 play active roles in recruitment of deacetylating enzymes to nucleosomes, and mediate key protein-protein and protein-DNA interaction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with several components of the Sin3A corepressor complex
  • interacting with SAP30 (are able to target Sin3A to the nucleolus)
  • associates with the core members of the SIN3A corepressor complex and is able to induce transcriptional repression presumably through SIN3A and class I HDACs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS