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FLASH GENE
Symbol FAAP24 contributors: mct - updated : 01-06-2009
HGNC name chromosome 19 open reading frame 40
HGNC id 28467
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1152 23.9 215 - Ciccia (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two HhH motifs necessary for interactions with FANCM (Ciccia 2007)
  • HOMOLOGY
    Homologene
    FAMILY
  • Fanconi anemia (FA) core complex family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for normal levels of FANCD2 monoubiquitylation following DNA damage
  • FANCM/FAAP24 complex may play a key role in recruitment of the FA core complex to damaged DNA
  • FANCM/FAAP24 complex is specifically required for the recruitment of replication protein A (RPA) to interstrand crosslinking (ICL)-stalled replication forks
  • FANCM and FAAP24 play multiple, while not fully epistatic, roles in maintaining genomic integrity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • DNA-binding component of the FA core complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacts with the C-terminal domain of FANCM and may cooperate with FANCM to target the FA core complex to damaged DNA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS