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FLASH GENE
Symbol DUOXA2 contributors: mct/npt - updated : 01-04-2020
HGNC name dual oxidase maturation factor 2
HGNC id 32698
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1755 35 320 - 2015 25761904
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   lowly
Endocrinethyroid   predominantly
Respiratoryrespiratory tract     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an external N terminal domain
  • a Kozak consensus domain
  • five membrane integral region
  • three NX (S/T) consensus site for N glycosylation clustered within an external connecting the second and third transmembrane helices
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila numb
    Homologene
    FAMILY
  • NADPH oxydase family, (NOX) family
  • DUOXA family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text ER-resident transmembrane protein
    basic FUNCTION
  • allowing ER-to-Golgi transition, maturation, and translocation to the plasma membrane of functional DUOX2 in a heterologous system
  • playing an important role in thyroid hormonogenesis
  • both DUOX2 and DUOXA2 expression are involved specifically in inflammation and are regulated on a crypt-by-crypt basis in ulcerative colitis tissue
  • essential role of DUOXA2 in thyroid hormone synthesi
  • both stability and function of the maturation factor, DUOXA2, are dependent on the oxidative folding of DUOX2, indicating that DUOX2 displays a chaperone-like function with respect to its partner
  • both DUOX enzymes (DUOX1, DUOX2) and their respective maturation factors DUOXA1 and DUOXA2 form a stable complex at the cell surface, which is fundamental for their enzymatic activity
  • H2O2 produced by the DUOX2/DUOXA2 cell surface enzymatic complex could provoke potential mutagenic DNA damage in an inducible cellular model
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DUOX2
  • thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL4 and IL13, through increased expression of the DUOX2 and its maturation factor DUOXA2
  • the maturation and activity of DUOX2 were drastically impaired when expressed with the glycosylation-defective maturation factor DUOXA2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HTDI2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS