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FLASH GENE
Symbol TM4SF1 contributors: - updated : 11-06-2007
HGNC name transmembrane 4 superfamily member 1
HGNC id 11853
RNA
TRANSCRIPTS type messenger
text use of alternate polyadenylation sites
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Reproductivefemale systembreast   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines lung,ovarian ,breast, colon carcinoma cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
three predicted NH2-terminal hydrophobic transmembrane regions which were followed by a hydrophilic region containing two potential N-linked glycosylation sites and a COOH-terminal hydrophobic transmembrane region
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Tm4sf1
homolog to C.elegans C09F12.1
Homologene
FAMILY
  • tetraspanin family (TM4SF)
  • transmembrane 4 superfamily
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION mediating signal transduction events that play a role in the regulation of cell development,activation,growth and motility
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component present in high molecular weight complexes in tumor cells
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS