basic FUNCTION
| playing an essential role in the initiation and elongation phases of genome duplication |
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GINS complex is a key factor for establishing the initiation complex after prereplicative complex assembly and important for the normal progression of the replisome |
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replication complex that in S phase, associates first with replication origins and then with neighboring sequences (Takayama 2003) |
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essential for initiation of DNA replication and S phase progression and directly involved in cellular processes |
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necessary for proliferation and viability (Aparicio 2009) |