basic FUNCTION
| increasing proliferation of preadipocytes |
|
regulates the functions of IR-1 and AKT1, decreases SLC2A4 translocation and reduces glucose uptake in response to insulin |
|
may be an important mediator in the development of obesity-related insulin resistance |
|
involved in obesity-associated insulin resistance |
|
regulatory function in adipocyte insulin sensitivity |
|
potential role in glucose homeostasis and the development of insulin resistance in obesity |
|
PID1 is a potent intracellular inhibitor of insulin signaling pathway during obesity |
|
PID1 may likely have a tumor inhibitory function in these pediatric and adult brain tumors |
|
PID1 serves as an insulin-regulated retention adaptor protein controlling translocation of LRP1 in conjunction with SLC2A4 to the plasma membrane of adipocytes |
|
PID1 in adipose tissue increases lipolysis by altering the antilipolytic action of insulin |