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FLASH GENE
Symbol REEP6 contributors: mct - updated : 05-04-2016
HGNC name receptor accessory protein 6
HGNC id 30078
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1393 - 184 in the retina, specifically expressed in rod photoreceptors of developing and mature retina 2014 24691551
  • Reep6.1
  • includes 27 additional amino acids encoded by exon 5
  • is a key functional target of NRL-centered transcriptional regulatory network in rod photoreceptors
  • - - 1635 - 211 - 2014 24691551
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousnervecranial nerve  highly
    Reproductivemale systemtestis  highly
    Visualeyeretina  highly Homo sapiensFetal
     eyeretina    Homo sapiensAdult
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualganglion cell
    Visualrod photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    common domain REEP5/DP, and HVA22
    HOMOLOGY
    Homologene
    FAMILY
  • DP1 family
  • YOP1/TB2/DP1/HVA22 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • may enhance the cell surface expression of odorant receptors
  • probably playing an important role in intracellular membrane trafficking in retinal ganglion cells
  • displays pro-apoptotic activity and was proposed to be a tumor suppressor
  • membrane shaping adapter protein that modulate specific G protein-coupled receptor trafficking by affecting ER cargo capacity
  • implicated in retinal homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with odorant receptor proteins
  • is a key functional target of NRL-centered transcriptional regulatory network in rod photoreceptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RP77
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a diagnostic marker for colon cancer and inflammatory bowel disease (IBD)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    may be a therapeutic target for colon cancer
    immunologyinflammatory 
    may be a therapeutic target for IBD
    ANIMAL & CELL MODELS