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FLASH GENE
Symbol UTP20 contributors: mct - updated : 28-06-2022
HGNC name UTP20, small subunit (SSU) processome component, homolog (yeast)
HGNC id 17897
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
62 - 9031 - 2785 - 2010 21151873
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Nervousnerve   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • multiple HEAT-repeat motifs (Huntington, elongation factor 3, a subunit of protein phosphatase 2A, target of rapamycin)
  • a single region located between amino acids 2744 and 2761 at the C-terminus capable of nucleolar accumulation
  • a nucleolar targeting sequence in its 3'-terminus
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • is involved in 18S rRNA processing
  • BMS1 and UTP20 are required for the recruitment of a subset of proteins to nascent pre-ribosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with UBTF at the rDNA promoter
  • cell & other
    REGULATION
    activated by USF2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast carcinoma, metastatic
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS