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FLASH GENE
Symbol WDR45B contributors: mct - updated : 10-10-2022
HGNC name WD repeat domain 45B
HGNC id 25072
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2496 - 344 - 2022 36173873
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrineparathyroid   highly
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two WD40 repeats
  • two sites embedded in blades 5 and 6 for recognizing phosphoinositides, resembling that in Hsv2
  • secondary structure seven-bladed beta-propeller structure
    HOMOLOGY
    Homologene
    FAMILY WIPI subfamily of WD40 repeat proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions
  • WIPI proteins function as essential phosphatidylinositol 3-phosphate (PtdIns3P) effectors at the nascent autophagosome
  • WDR45B is likely critical for neural homeostasis
  • novel function of WDR45/45B in autophagosome-lysosome fusion
  • WDR45 and WDR45B are critical for autophagosome-lysosome fusion in neural cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WDR45B associates with AMPK-activated TSC complex at lysosomes, regulating MTOR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEDSBAS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice deficient in Wdr45b exhibit motor deficits and learning and memory defects; Histological analysis reveals that Wdr45b knockout (KO) mice exhibit a large number of swollen axons and show cerebellar atrophy