protein
| binding to the putative human homolog of S.cerevisiae Rad23p |
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interactiong with CETN2 (localization of centrin-2 within the nucleus depends on its ability to bind to the XPC protein) |
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interacting with RAD23B, to recognize DNA damage in global genomic repair |
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RAD23A, RAD23B facilitate lesion recognition by XPC but do not participate in the downstream DNA repair process |
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RNF111 promoted ubiquitylation of SUMOylated XPC (xeroderma pigmentosum C) protein, a central DNA damage recognition factor in nucleotide excision repair (NER) |
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XPC allows DDB2 to initiate multiple rounds of repair events, thereby contributing to the persistence of cellular DNA repair capacity |
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CDH1 promotes nucleotide excision repair through positively regulating the expression of xeroderma pigmentosum complementation group C (XPC) and DNA damage-binding protein 1 (DDB1) |
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PARP1 plays an additional DDB2-independent direct role in recruitment and stabilization of XPC at the UV-induced DNA lesions to promote nucleotide excision repair (GG-NER) |
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