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FLASH GENE

Symbol

GPR174

contributors: mct - updated : 20-09-2014

HGNC name	G protein-coupled receptor 174
HGNC id	30245

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032553 1 - 1258 NP_115942 - 333 - 2014 24891334

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Gpr174 (88.3pc)

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may have a purinergic nucleotide receptor activity
	negatively regulates immune-cell proliferation by increasing intracellular cAMP
	may play important roles in the central nervous system as a lysophosphatidylserine (LysoPS) receptor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Graves disease

Variant & Polymorphism SNP	rs3827440 associated to Graves disease

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS