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FLASH GENE
Symbol L3MBTL3 contributors: mct - updated : 02-05-2018
HGNC name l(3)mbt-like 3 (Drosophila)
HGNC id 23035
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 4429 88.2 780 - 2017 29030483
  • isoform a
  • 22 - 4354 85 755 - 2017 29030483
  • lacking an alternate in-frame exon
  • isoform b has the same N- and C-termini but is shorter
  • 22 - 4236 - 755 - 2017 29030483
    22 - 4128 - 755 - 2017 29030483
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine  highly
    Endocrineadrenal gland    
    Nervousnervecranial nerve  highly
    Reproductivemale systemtestis   
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three MBT repeats
  • one SAM (sterile alpha motif) domain
  • HOMOLOGY
    interspecies homolog to murine L3mbtl3 (88.0pc)
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • Polycomb group protein specifically regulating the maturational advancement of myeloid progenitor cells during transitions between two developmental stages
  • may be influencing myelopoiesis by transiently enhancing p57(KIP2) expression levels
  • recognizes mono- and dimethylated lysine residues on histone tails
  • L3MBTL3 engages likely methylated histone tails as a dimer while carrying out its normal function, providing an explanation for the presence of repeated MBT domains within L3MBTL3
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in the absence of NOTCH intracellular domain (NOTCH ICD), RBPJ recruits L3MBTL3 and the histone demethylase KDM1A (also known as LSD1) to the enhancers of Notch target genes, leading to H3K4me2 demethylation and to transcriptional repression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS