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FLASH GENE
Symbol KAZALD1 contributors: - updated : 13-07-2006
HGNC name Kazal-type serine peptidase inhibitor domain 1
HGNC id 25460
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Reproductivefemale systembreastmammary gland highly
 male systemprostate  highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Ig-like C2-type (immunoglobulin-like) domain
  • a IGFBP domain
  • a Kazal-like domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Kazald1 (84.2pc)
    homolog to rattus Kazald1 (85.2pc)
    Homologene
    FAMILY IGFBP superfamily
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION involved in the proliferation of osteoblasts during bone formation and bone regeneration
    CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS ossification
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by BMP2
    Other up-regulated at the early phase of bone regeneration
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS