basic FUNCTION
| has an important role in hematopoiesis and in the pathogenesis of myelodysplasia and myeloid malignancies |
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implicated in myeloproliferative neoplasm and myelodysplastic syndromes through the identification of acquired mutations affecting hematopoietic stem cells |
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PARP1 and TET2 contribute to an epigenetic program that directs subsequent transcriptional induction at pluripotency loci during somatic cell reprogramming |
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enzyme that catalyzes the conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5-hmC) |
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has a critical role in survival and hematopoietic stem cell homeostasis |
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implicated in hematopoietic differentiation and the formation of myeloid malignancies when mutated |
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is critical for the full activation of >50 genes that become upregulated during pre-B cell to macrophage transdifferentiation |
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TET2-dependent O-GlcNAcylation of chromatinand the double epigenetic modifications on both DNA and histones by TET2 and OGT coordinate together for the regulation of gene transcription |
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TET2, TET3 are required for 5-hydroxymethylcytosine (5hmC) enrichment at enhancers, a condition necessary for expression of adjacent genes |
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neuronal TET2 is positively involved in the regulation of cell survival |
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in the absence of TET2, mast cell differentiation is under the control of compensatory mechanisms mediated by other TET family members, while proliferation is strictly dependent on TET2 expression |
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molecular circuitry in which opposing functions of TET1 and TET2 control acquisition of alternative pluripotent states |
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TET1, TET2, TET3 influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling |
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TET2 plays a role in the iron and heme metabolism in erythroblasts |
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distinct roles for TET2 and TET3 in human erythropoiesis |
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TET2-mediated DNA demethylation promotes the expression of ferroportin and erythroferrone against oxidative stress |
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protective role of TET2 in erythroid iron homeostasis against oxidative stress and erythropoiesis |
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TET2 catalyzes the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine, leading to DNA demethylation, and also affects transcription by recruiting histone modifiers |
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TET2 is an important regulator of CD8+ T cell fate decisions |
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TET1 and TET2 play a critical role in maintaining bone marrow MSCs and bone homeostasis through demethylation of P2RX7 to control exosome and miRNA release |
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TET2 was found to be a promoter of both osteogenesis and adipogenesis |
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TET2 and TET3 are guardians of Treg cell stability and immune homeostasis |
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promotes de-methylation of DNA by catalyzing conversion of methylation to 5-hydroxymethylation |