basic FUNCTION
| endothelium-derived vasoconstrictor peptides inducing several cellular responses, including the production of second messengers, diacylglycerol and inisitol-triphosphate |
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induces cortical neurite elongation through the endothelin A receptor (Uesugi 2009) |
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involved in hypertension, ovulation |
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chemoattractant for macrophages and THP-1 monocytic cells via a MAPK-mediated pathway (Grimshaw 2002) |
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would act in a cooperative manner with EDN1, giving to the villus the straight enough to withstand mechanical stress |
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plays potentially important roles in energy homeostasis, thermoregulation, and the maintenance of lung morphology and function |