Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EDN2 contributors: mct - updated : 19-03-2014
HGNC name endothelin 2
HGNC id 3177
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1258 17.4 178 - -
2.5kDa for the mature form
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheartatrium   
Digestiveintestinesmall intestineduodenum   Homo sapiens
 intestinesmall intestineileum   Homo sapiens
 intestinesmall intestinejejunum   Homo sapiens
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningendothelium  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text in the later stages of embryonic development in mouse
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
isoforms Precursor prepro VIC cleaved to Big Vic including a VIC-like peptide, then releasing mature VIC (EDN2)
HOMOLOGY
interspecies homolog to rattus Edn2 (68.0pc)
homolog to murine Edn2 (68.8pc)
Homologene
FAMILY
  • endothelin/sarafotoxin family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
    text secreted protein
    basic FUNCTION
  • endothelium-derived vasoconstrictor peptides inducing several cellular responses, including the production of second messengers, diacylglycerol and inisitol-triphosphate
  • induces cortical neurite elongation through the endothelin A receptor (Uesugi 2009)
  • involved in hypertension, ovulation
  • chemoattractant for macrophages and THP-1 monocytic cells via a MAPK-mediated pathway (Grimshaw 2002)
  • would act in a cooperative manner with EDN1, giving to the villus the straight enough to withstand mechanical stress
  • plays potentially important roles in energy homeostasis, thermoregulation, and the maintenance of lung morphology and function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • ligand for the endothelin receptors
  • EDN2/EDNRB are a regenerative pathway, suggesting that EDNRB agonists represent a promising therapeutic approach to promote myelin regeneration
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in basal cell carcinoma under control of Hedgehog signaling pathway
    tumoral       loss of function
    occurs frequently in colon cancers
    Susceptibility for essential hypertension
    Variant & Polymorphism other the EDN2 A985 allele may be a risk factor for atrial fibrillation in patients with hypertrophic cardiomyopathy (Nagai 2007)
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    could represent a potential target for chemopreventive or neoadjuvant therapeutics for clear cell renal cell carcinoma
    ANIMAL & CELL MODELS
  • Edn2 overexpression in the early embryo inhibits vascular development at midgestation, but Edn2 overexpression in developing skin and brain has no discernible effect on vascular structure
  • Edn2 overexpression in the developing mouse retina potently and specifically inhibits retinal angiogenesis and promotes the tip cell state