basic FUNCTION
| causing cardiac myocyte apoptosis and ventricular dysfunction |
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regulating macrophage activation |
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negative regulator in macrophage activation and implicated in host immunity and inflammatory diseases |
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plays an important role in both physiological and pathological processes related to inflammation |
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essential RNase that prevents immune disorders by directly controlling the stability of a set of inflammatory genes |
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essential role for preventing the development of severe immune diseases characterized by an increase in immunoglobulin-producing plasma cells and the formation of granulomas |
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having a functional role of CCCH zinc finger genes in the regulation of macrophage activation |
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expression caused induction of a variety of genes known to be involved in cell death |
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acts as a DUB to negatively regulate JNK and NFKB1 signaling and macrophage inflammation |
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functions as a negative regulator of the cytokine-induced inflammatory responses in vascular endothelial cells |
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functions as a RNase to regulate mRNA degradation, and negatively regulates adhesion molecules gene expression by inhibition of their transcription (as VCAM1) |
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may inhibits cytokines-initiated NF-KB signaling and thus limits VCAM1 gene transcription |
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is an equilibrium gatekeeper that not only regulates its own inducers but also controls the regulation by degrading its own mRNA |
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critical regulator of the inflammatory response and immune homeostasis |
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coordinates stress granules formation and apoptosis during cellular stress and may play a critical role in immune homeostasis and resolution of macrophage inflammation |
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may promote cellular apoptosis by disassembling SGs and releasing apoptosis-inducing components |
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functions as a factor to coordinate formation and apoptosis during cellular stress, which may be implicated in the resolution of macrophage inflammation and immune homeostasis |
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potent regulator of innate immunity, which can be strongly engaged in the pathogenesis of acute and chronic infective diseases (PMISD: 22777400) |
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down-regulates IL2 via an ARE-independent pathway |
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destabilizes its own mRNA, thereby preventing excessive translation of Regnase-1 and degradation of cytokine-encoding mRNAs |
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possible involvement of ZC3H12A up-regulation in toxic properties of proteasome inhibition, which is an acknowledged approach to the treatment of several cancer types |
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prominent role in the control of inflammation and immune homeostasis |
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MCPIP1 endoribonuclease activity negatively regulates IL17-mediated signaling and inflammation |
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plays a crucial anti-inflammatory role not only in myeloid cells but also in epithelial cells |
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plays an important role in early cortical neurogenesis but also reveal an unexpected link between neocortical development, immune regulators, and epigenetic modification |
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contributes to the clear cell renal cell carcinoma (ccRCC) development (28197812) |
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is a master RNA regulator in macrophages and T cells that degrades cellular and viral RNA upon NFKB1 signaling |
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ZC3H12A, like ZC3H12C, is an RNase essential for immune homeostasis but has diverged as key regulator in the IFN pathway in macrophages |