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FLASH GENE
Symbol DDX59 contributors: mct - updated : 17-10-2014
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
HGNC id 25360
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2337 68.7 619 - 2013 23972372
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouthpalate    Mus musculusFetal
Endocrineneuroendocrinepituitary  highly
Reproductivefemale systemuteruscervix  
Skeletonappendicular skeletonupper limb    Mus musculusFetal
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a HIT-type zinc finger
  • a Q motif
  • an helicase ATP-binding domain
  • a DEAD box
  • an helicase C-terminal domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Ddx59 (84 pc)
    homolog to murine Ddx59 (83.5 pc)
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX59 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • dynamically to the nucleus and the cytoplasm
  • basic FUNCTION
  • playing an helicase role
  • controlling ATP binding and hydrolysis through its Q motif
  • play a critical role in all aspects of RNA metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule metal binding, nucleotide,
  • Zn2+
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OFD5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS