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FLASH GENE
Symbol CRELD2 contributors: mct/pgu - updated : 16-10-2013
HGNC name cysteine-rich with EGF-like domains 2
HGNC id 28150
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1353 - 321 - 2006 16919896
  • variant alpha
  • lacking exons 6, 8a, 9 & 10a
  • 10b terminal exon
  • product predicted to be secreted into the extracellular space
  • - splicing - - 284 - 2006 16919896
  • lacking exon 6
  • 8a terminal exon
  • product predicted to be localized to the ER
  • - splicing - 38 353 - 2006 16919896
  • lacking exons 6, 8a & 10a
  • 10b terminal exon
  • product predicted to be secreted into the extracellular space
  • - splicing 1365 - 325 - 2006 16919896
  • variant Gamma
  • lacking exons 6, 8, 8a & 10a
  • 10b terminal exon
  • product predicted to be secreted into the extracellular space
  • - splicing - - 402 - 2006 16919896
  • lacking exons 8a & 10a
  • 10b terminal exon
  • product predicted to be secreted into the extracellular space
  • - splicing - - 373 - 2006 16919896
  • lacking exons 6 & 8a
  • 10a terminal exon
  • product predicted to be secreted into the extracellular space
  • 11 - 1575 - 402 - 2006 16919896
  • isoform a
  • 10 - 1428 - 353 - 2006 16919896
  • isoform b
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestineduodenum moderately
     intestinelarge intestinecaecumappendix vermicularmoderately
     salivary gland   moderately
     stomach   predominantly
    Endocrinepancreas   predominantly
     thyroid   moderately
    Respiratoryrespiratory tracttrachea  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text lung, liver, thymus, spleen and heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tryptophan-glutamic acid rich domain (WE)
  • EGF binding domain
  • Ca binding domain
  • EGF/Ca binding domain
  • furin cysteine-rich domain
  • HOMOLOGY
    interspecies homolog to rattus Creld2 (77,08 pc)
    homolog to murine Creld2 (75,71 pc)
    Homologene
    FAMILY
  • CRELD family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text localized in ER
    basic FUNCTION
  • secreted CRELD2 isoforms may modulate CRELD1 function by competitive binding
  • may acts as an extracellular competitor of CRELD1
  • CRELD2 may regulates CRELD1 function
  • may play a role in AVSD
  • could be a novel mediator in regulating the onset and progression of various ER stress-associated diseases
  • MANF and CRELD2 are genotype-specific ER stress response proteins with substrate specificities
  • exogenous CRELD2 promotes GDF2-induced ectopic bone formation and matrix mineralization, whereas silencing CRELD2 expression diminishes GDF2-induced bone formation and matrix mineralization
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CRELD2 may be directly regulated by GDF2
  • CRELD2 and MANF, are oppositely regulated by the overexpression of 78&
  • 8201;kDa glucose-regulated protein (HSPA5)
    cell & other
    REGULATION
    induced by ER stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS