basic FUNCTION
| function as E3 ligases based on its capacity for self-ubiquitination (Takeyama 2003) |
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regulates the subcellular localization of PARP9 by a dynamic shuttling mechanism, highlighting the functional requirement for coordinated DTX3L and PARP9 expression (Juszczynski 2006) |
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selectively monoubiquitylates histone H4 lysine 91 and protects cells exposed to DNA-damaging agents (Yan 2009) |
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directly implicated in the monoubiquitylation and additional posttranslational modification of histone H4 and an associated DNA damage response (Yan 2009) |
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selectively monoubiquitylates histone H4 lysine 91 and protects cells exposed to DNA-damaging agents |
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directly implicated in the monoubiquitylation and additional posttranslational modification of histone H4 and an associated DNA damage response |
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E3 ligase that regulates subcellular localization of its partner protein, PARP9, by a dynamic nucleocytoplasmic trafficking mechanism |
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selectively ubiquitylates histone H4 and indirectly promotes early TP53BP1 recruitment to DNA damage sites |
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DTX3L and PARP9 are bona fide members of a DNA damage response pathway and are directly associated with PARP1 activation, BRCA1 recruitment, and double-strand break repair |
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novel role for the really interesting new gene-domain E3 ubiquitin ligase deltex-3-like (DTX3L) in regulating CXCR4 sorting from endosomes to lysosomes |
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DTX3L and PARP9 act together as repressors of the tumor suppressor IRF1 in prostate cancer cells |