SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic,vesicle
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text
| localizes to early and late endosomes as well as to synaptic vesicles (SV) |
basic FUNCTION
| required for normal NADPH oxidase activation in response to both particulate and soluble stimuli |
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may be playing an important role in neuronal cell function through regulation of membrane excitability by protein kinase C |
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involved in oxidant-dependent events in the polymorphonuclear leukocyte, including endotoxin priming and the maintenance of cellular quiescence |
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is important in volume-regulated anion channel Cl(-) currents function and cell volume regulation, and participates in the fibroblast-to-myofibroblast transition |
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innvolved in premitotic condensation that is an integral part of cell division, and is a critical regulator of the cell cycle in normal and malignant glial cells ( |
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may contribute to the acidification of synaptic vesicles and endosomes |
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function in osteodifferentiation may be through the RUNX2 pathway |
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required for endosome-dependent signaling by the Nox1 NADPH oxidase in smooth muscle cells |
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might likely be important for normal excitatory and/or inhibitory neurotransmission in central neurons |
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controls fast excitatory synaptic transmission by regulating the amount of neurotransmitter as well as the release probability of synaptic vesicles (SV) |
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CLCN3 chloride channel acts likely as a mechanically sensitive channel to regulate osteodifferentiation in osteoblasts |
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CLCN3 and CLCN5 are necessary components for S1P-induced excitatory Cl- currents but not for the amplification of TRPV1-mediated currents in sensory neurons |
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