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FLASH GENE
Symbol BRWD3 contributors: mct - updated : 09-10-2017
HGNC name bromodomain and WD repeat domain containing 3
HGNC id 17342
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
45 - 12793 - 1802 - Kalla
  • BRWD-3A
  • - - 6017 - 1631 - Kalla
    - - 6078 - 1398 - Kalla
    - - 5833 - 1472 - Kalla
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight N-terminal WD40 repeats, that may facilitate the formation of protein complexes
  • two C-terminal bromodomains
  • HOMOLOGY
    interspecies homolog to murine Brwd3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION acts as a positive regulator of the JAK/STAT
    signaling pathway
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRX93
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
          --low  
    downregulated in a majority of 22 BCLL cases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • increased in breast cancer plasma, confirming for its diagnostic value as serum marker
  • EMBO Rep. 2015 Apr;16(4):528-38. doi: 10.15252/embr.201439092. Epub 2015 Feb 9. Erratum in: EMBO Rep. 2016 Jul;17(7):1082. Liu, Kuei-Yan [corrected to Liu, Kwei-Yan].
    Therapy target
    ANIMAL & CELL MODELS
    in vivo analysis demonstrated that disrupted Drosophila BRWD3 and overexpressed Ptp61F function as suppressors of leukemia-like blood cell tumors